Pinch-hitter Chris Heisey delivered a game-winning single with one out in the bottom of the ninth inning to give the Reds a 1-0 victory over the Cardinals on Wednesday night. Left-hander Tony Cingrani threw seven shutout innings, allowing two hits and striking out nine, opposite Cardinals starter Michael Wacha’s 6 2/3 scoreless frames.

Jarred Cosart, who dazzled in his rookie debut a year ago, picked up where he left off by throwing five scoreless innings and benefiting from a first-inning homer from Dexter Fowler to beat the Yankees, 3-1, on Wednesday at Minute Maid Park. The Astros are now 2-0 for the first time since 2003.

The Cubs finally scored a run, thanks to an overturned call after manager Rick Renteria challenged a play at second on Wednesday in Chicago’s 4-3 loss to the Pirates. The Cubs lost a challenge in the 13th, but were able to escape a bases-loaded jam.

Pirates manager Clint Hurdle’s challenge record fell to 1-1 in the eighth inning of Wednesday’s 4-3 win against the Cubs, when a call confirmed that Starling Marte had struck out by bunting a two-strike pitch foul.

After two nights of scattered but ultimately unfruitful offense, the Rockies put together just enough production for their first victory of the season, 6-5, over the Marlins on Wednesday night at Marlins Park in front of 15,866.

The Rangers stunned reliever Jonathan Papelbon with three runs in the bottom of the ninth for a 4-3 victory over the Phillies on Wednesday night at Globe Life Park.

Blue Jays left-hander Mark Buehrle struck out 11 and came within one out of his 10th career shutout, while Jose Bautista hit a pair of solo home runs en route to a 3-0 win over the Rays on Wednesday night at Tropicana Field.

Gio Gonzalez allowed one run over six innings, and added a solo homer as the Nationals topped the Mets, 5-1, on Wednesday night at Citi Field in New York. Ian Desmond also homered, while Adam LaRoche had an RBI double and Denard Span scored two runs.

Unlike Opening Day, when the Red Sox bats were held mostly silent, there was timely thump en route to a 6-2 victory over the Orioles on Wednesday night.

Rockies outfielder Carlos Gonzalez was removed from Wednesday’s 6-5 victory over the Marlins in the bottom of the sixth inning because of dizziness, which he believes was from dehydration.

The Astros on Wednesday picked up where they left off last season, honoring a legendary Yankee, this time Derek Jeter. The array of gifts screamed “Texas”: pinstriped cowboy boots and a Stetson.

Left of the scoreboard at Angel Stadium, above the grassy area in center field and below the flags, sits a 10-foot sign that will count down Albert Pujols’ quest to reach 500 career home runs.

As Giants manager Bruce Bochy saw it Wednesday, baseball’s new replay system saved him some fine money. Noting that he regarded four separate umpires’ calls as worth reviewing during San Francisco’s 5-4 loss Tuesday to Arizona, Bochy said that in any previous season, “I probably would have gotten thrown out of that game, that’s for sure.”

Seahawks quarterback Russell Wilson made another appearance for the Rangers on Wednesday, throwing out the ceremonial first pitch before their game with the Phillies.

Scott Kazmir took the mound Wednesday afternoon for a matinee affair against his former Indians teammates and simply dominated them, allowing just three hits in the five-strikeout performance, a 7 1/3-inning joyride that guided the A’s to a 6-1 victory.

Outfielder Peter Bourjos, acquired from the Angels in November, is eager to partake in the Cardinal Way, something he says you’ve got to see to believe.

In the wake of a 2-1, 10-inning walk-off win against the Royals on Wednesday — in a game in which Tigers manager Brad Ausmus went 2-for-2 in the challenge department, with the second playing a particularly big role in the result — there were certainly no complaints about the system’s efficacy or Ausmus’ ability to navigate it.