Since his no-hitter, Johan Santana is winless with an unsightly ERA in five starts. Uncertainty for next season already is in place.

On Thursday at Fenway Park, the Angels will be looking for their first sweep of Boston since July 2008 as left-hander C.J. Wilson takes the mound opposite Boston's Franklin Morales.

Tennessee and Japan are one win away from a berth in the Little League World Series' title game on Sunday thanks to victories in their respective winners' bracket finals on Wednesday

Left-hander Andrew Werner earned a victory in his Major League debut, allowing two runs on four hits over six-plus innings. Carlos Quentin drove in three runs as the Padres completed a sweep of the Pirates on Wednesday, 4-2.

Scott Diamond will try to stop a powerful Rangers lineup in Thursday's opener. Roy Oswalt will fill in for the injured Yu Darvish.

After the Braves and the Giants each finished critical series Wednesday pitting the top two teams in their respective divisions against each other, the two clubs will open a four-game set in San Francisco on Thursday night.

Right-hander Jason Marquis will miss his next start and is likely headed to the disabled list after he suffered a fractured trapezium bone in his left hand on Tuesday.

Thursday's contest in Philadelphia will almost surely have implications beyond deciding the series outcome between the Reds and the Phillies.

Tightness in catcher Buster Posey's right hamstring forced the Giants to scratch him from the lineup for Wednesday night's series finale against the Los Angeles Dodgers, though he's not considered seriously injured.

Cavan Biggio, the youngest son of Astros legend Craig Biggio, is among 20 players who have been selected to play for the United States in the 2012 International Baseball Federation 18-and-under/AAA World Championships in South Korea, Aug. 30-Sept. 8.

Ryan Braun and the Brewers visit Pittsburgh for the first time this year over the weekend, where they begin a three-game set on Friday.

Angels first baseman Albert Pujols left Wednesday's game against the Red Sox in the bottom of the fourth inning, the result of tightness in his right calf.

Eric Thames hit a two-out, two-run double in the eighth inning Wednesday to propel the Mariners to a 3-1 win over the Indians at Safeco Field.

Yankees captain Derek Jeter shrugged off an ESPN commentator's suggestion on Wednesday that his performance this season may have received artificial assistance, calling the statements “unfortunate.”

Tyler Skaggs allowed just two runs and three hits in 6 2/3 innings in his Major League debut as the D-backs won the opener of the first doubleheader at Chase Field, 3-2, vs. the Marlins.

The A's turn to right-hander Tyson Ross to replace Bartolo Colon, who was suspended 50 games for testosterone use, as they open a three-game series against Alex Cobb and the Rays on Thursday at Tropicana Field.

Mike Trout's rookie season has been one for the ages. The center fielder's first 100 games are unmatched by any rookie in Major League history.