Just when it looked like the Angels were about to regret another night full of wasted opportunities, Erick Aybar hit a tiebreaking homer in the ninth on Wednesday, giving the Angels a 2-1 win in the Freeway Series finale at Dodger Stadium.

Matt Cain's perfect game gave Major League Baseball five no-hitters in the span of 53 days. It is a string of unparalleled success, but it is not the only time in baseball history when no-hitters have appeared as contagious as the common cold.

Each day, MLB.com selects one player from each game whose performance stands out.

The Astros shuffled around the visitors' clubhouse at AT&T Park late Wednesday night, quickly eating plates of food and quietly getting dressed. It could have been a scene following any loss, but this night was anything but ordinary.

Matt Cain's perfect game extends a line of San Francisco pitchers, including a pair of Hall of Famers, who posted no-hit efforts and etched their spot in San Francisco lore.

Matt Cain had come so close so many other times that this one seemed inevitable. His teammates probably are the least surprised people on Earth.

For the Giants, it will go down as one of the most magical moments in the history of a storied franchise. For the Astros, they'll be remembered as the unlucky bunch that ran into a pitcher destined for a place in history.

Yonder Alonso broke a scoreless tie with a home run and Jason Marquis tossed 6 1/3 shutout innings on Wednesday to lead the Padres to a 1-0 victory over the Mariners in front of 13,931 at Safeco Field.

Indians starter Derek Lowe had some harsh words for Reds manager Dusty Baker after being brushed back by a fastball from Reds right-hander Mat Latos in the fifth inning on Wednesday night.

The A's offense came up with 10 runs, including three in a comeback ninth inning against the Rockies, to win a 10-8 slugfest in Denver.

Mike Moustakas' bases-loaded walk in the 11th inning gave the Royals a 4-3 victory over the Milwaukee Brewers in front of 17,885 at Kauffman Stadium. Fittingly, the walk gave the Royals their first walk-off victory this season.

Matt Cain hurled the first perfect game in the Giants' 129-year history Wednesday, subduing the Houston Astros in a 10-0 decision at AT&T Park.

The Yankees concluded a three-game sweep of the Braves on Wednesday night with a 3-2 victory in front of a sellout crowd of 48,938 at what amounted to Yankee Stadium South: Turner Field.

Lance Lynn struck out a career-high 12 for his 10th win and Carlos Beltran hit a solo shot as the Cardinals beat the White Sox, 1-0, on Wednesday at Busch Stadium.

The Tigers made up a three-run deficit in one inning for the second straight night against the Cubs. This time, Detroit finished the comeback convincingly in an 8-4 victory Wednesday night at Wrigley Field.

The Rangers scored just once, but thanks to Matt Harrison, that proved to be all the offense they needed in a 1-0 win over the D-backs at the Ballpark in Arlington on Wednesday night.

After 50 long years without a no-hitter, the Mets could be one generous decision away from recording two in less than two weeks.