Happy, high-pitched voices resonated from Diez Park in Houston on Thursday, sounds that indicated the hundreds of kids participating in Major League Baseball’s PLAY BALL event were, in fact, having a great time playing ball.

There was no serious no-hit drama for Adam Conley, but the 25-year-old lefty continues to piece together scoreless innings. Conley tossed 5 1/3 shutout innings, and Christian Yelich blasted a two-run homer in the eighth as the Marlins defeated the D-backs, 4-0, on Thursday night, completing a three-game sweep at Marlins Park.

Astros second baseman Jose Altuve met a boy with terminal cancer on the field before Thursday’s game who asked him to hit a home run. Altuve delivered and then some, walloping a homer in his first at-bat to spark a 4-for-4 night in a 6-3 loss to the Mariners at Minute Maid Park.

When David Ortiz decided that 2016 was going to be his final Major League season, he gave Commissioner Rob Manfred a heads-up before the news became public. Manfred was appreciative of the gesture — and of the fine career Ortiz has produced.

Mike Trout is at it again. After a slow start, the Angels center fielder has found his footing and entered Thursday third in the Majors with 2.0 wins above replacement.

The Reds played perhaps their best game of 2016, with Alfredo Simon pitching into the eighth inning and getting plenty of offense — including home runs from Jay Bruce, Brandon Phillips and Adam Duvall — in a 9-5 win over the Brewers on Thursday.

The Rangers’ consistent run of starting pitching finally suffered a blip on Thursday night in Texas’ 12-2 loss to the Blue Jays at Rogers Centre.

With Andrew Miller warm in the bullpen and the game scoreless in the 10th, the Yankees opted for Johnny Barbato to start the frame. Barbato permitted two singles before Miller was summoned in an emergency effort, and he surrendered Pedro Alvarez’s game-winning sacrifice fly.

Not executing a sacrifice bunt ended up paying huge dividends for the Marlins in the eighth inning. Christian Yelich, with a runner on second, attempted a bunt that squibbed foul.

The hot starts by the Cubs and White Sox, who entered Thursday with the best records in the National and American Leagues, are the talk of the town, and their success has caught the eye of Commissioner Rob Manfred, too.

Colin Rea couldn’t quite finish off his bid at Padres no-hit history Thursday night. But, if anything, Rea’s outing in a 5-3 victory over the Mets reinforced the notion that the future is clearly very bright for the 25-year-old right-hander.

Edwin Encarnacion might be a traditionally slow starter, but he owns the month of May. Encarnacion’s 32 home runs in May since 2013 are the most by anyone in baseball. Toronto’s veteran slugger went 3-for-4 with a home run, two doubles, a walk and six RBIs in Thursday’s win over the Rangers.

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Cubs outfielder Jason Heyward, who has missed the last four games because of a sore right wrist, did everything on Thursday as if he was starting in hopes that he can return to the lineup on Friday.

In a 9-4 victory over the Tigers that completed a three-game series sweep, Michael Brantley drove in three runs, churned out four hits and made an impressive running, tumbling catch at a critical point in the game.

The Yankees have now played all their opponents in the always-tough American League East, and they go home to face the Red Sox for a three-game set again this weekend.

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