After scoring a total of two runs in the first two games, both losses, Red Sox manager Bobby Valentine shuffled his lineup on Sunday afternoon for the finale of a three-game series vs. the Tigers.

Andy Pettitte will make the first start of his comeback attempt on Monday for the Class A Advanced Tampa Yankees, manager Joe Girardi said.

A day after getting shellacked by the Tigers in his first start of 2012, Red Sox right-hander Josh Beckett reported no ill effects from the ailing right thumb that bothered him at times during Spring Training.

Charlie Morton is set to make possibly his one-and-only rehab start Monday night and A.J. Burnett, who will make another rehab start Wednesday, could be pitching for the Bucs “before the end of the month.”

Tim Hudson enjoyed three pain-free innings while pitching for Class A Rome against Charleston on Saturday night. The 36-year-old right-hander is aiming to rejoin the Braves' rotation during the series against the Pirates at the end of the month.

Braves right-handed pitcher Livan Hernandez entered Saturday afternoon's game against the Mets to face Lucas Duda with two on and one out in the fifth inning. Duda was just 10 when the veteran hurler made the only previous relief appearance of his career.

Jim Thome found himself in the starting lineup and playing first base in Sunday's series finale against the Pirates. It was the first time he started a game at first base since June 13, 2007, when he played for the Chicago White Sox.

Don't try to do too much is the message that's been delivered to Hanley Ramirez. There was a sense that Ramirez was pressing in his first two games, as the Miami third baseman went 0-for-8.

A day after getting treatment for his strained right lat (back) muscle in New York, Nationals outfielder Michael Morse was back in the lineup for Double-A Harrisburg on Sunday.

The question of who will take Doug Fister's spot in the Tigers' rotation appeared just as difficult to answer Sunday morning as the question of how long Fister will be out with his left side strain.

The Cardinals no longer have the game's most feared hitter, but they do have more than enough left on their roster to compete for another World Series title.

At 49 years and 141 days old Saturday, the Rockies' Jamie Moyer became the second-oldest pitcher to make a start, behind only Satchel Paige, who was 59 when he made his final start in 1965.

Class A Potomac third baseman Anthony Rendon suffered a badly sprained left ankle while running the bases in a 7-2 loss to Lynchburg on Saturday. It's not known how many games he will miss.

White Sox right-hander Gavin Floyd and Rangers left-hander Matt Harrison will take the mound Sunday night in Texas trying to avoid their usual early-season disappointments.

Yoenis Cespedes hit a titanic two-run blast to help make his regular-season debut in Oakland memorable, but the A's fell to the Mariners, 7-3, on Friday.

Friday night didn't feel like just any Opening Day for Albert Pujols. It was his first under the weight of a $240 million contract, his first without a Cardinals jersey on and his first in front of a West Coast fan base eager to see great things.

Kyle Seager's two-run single highlighted a four-run third inning and helped make a winner of Jason Vargas, as the Mariners beat the A's, 7-3, on Friday night.