Chris Young's two-run homer in the 11th inning on Tuesday gave the D-backs a 4-2 victory over the Padres at Petco Park and their first 4-0 start in franchise history.

A few years ago, Bruce Chen and Brandon McCarthy were fighting for Major League survival. Now, they're the de facto aces of their respective ballclubs. The two hurlers will square off on Wednesday when the Royals and Athletics meet for the final contest of their three-game set.

Left-hander Danny Duffy allowed one hit over six scoreless innings as the Royals beat the A's, 3-0, in a rain-shortened game on Tuesday in Oakland.

With most of Milwaukee's hitters clad in head warmers, appearing equally suited for a snowmobile ride, a bank robbery or a baseball game, the Brewers scored five runs before Paul Maholm recorded his third out and held on for a 7-4 win at frigid Wrigley Field on Tuesday night.

Coming off a subpar Opening Day start, CC Sabathia will try to improve to 17-2 lifetime against the Orioles and lead the Yankees to a sweep at Camden Yards in the process when he opposes Jake Arrieta on Wednesday night.

Jon Lester's second start of 2012 for the Red Sox comes in the rubber match against the Blue Jays and their ace Ricky Romero on Wednesday in a match-up of southpaws at Toronto's Rogers Centre.

After stumbling through the first four games of the season, the Braves welcomed Chipper Jones back on Tuesday. He showed no signs of rust, providing a much-needed spark with a tiebreaking third-inning homer that propelled his team over the Astros, 6-4.

Nationals third baseman Ryan Zimmerman collected his 500th RBI in a 6-2 victory against the Mets on Tuesday night. He became the first member of the Nationals to accomplish such a feat.

Royals center fielder Lorenzo Cain started a rousing double play in the second inning, but an inning later was taken out of the game with a left groin strain.

Raul Ibanez provided the Yankees with the big hit that they'd been searching for all night, delivering a go-ahead ground-rule double that powered a 5-4 victory over the Orioles in 12 innings on Tuesday at Camden Yards.

Ross Detwiler pitched five scoreless innings and helped the Nationals defeat the Mets, 6-2, at Citi Field on Tuesday, with Jayson Werth leading the offense.

The Mets' defense betrayed them, their bullpen became mortal, their offense grew stagnant and their perfection dissolved Tuesday night at Citi Field in a 6-2 loss to the Nationals, their first defeat of the season.

David Murphy's RBI single drove in the only run in the Rangers' 1-0 victory on Tuesday night, but baserunning also came up big in the second inning.

The Mets should have no problem drawing a crowd to Citi Field on Wednesday, when Nationals fireballer Stephen Strasburg and ace Johan Santana face off in the series finale.

Cubs starter Ryan Dempster is 15-5 with a 2.75 ERA in his career against the Brewers, who have taken the first two games of the four-game series at Wrigley. Yovani Gallardo starts for Milwaukee.

Aiming to guide the Braves to a win on Wednesday to close out their six-game road trip will be young righty Randall Delgado, while the Astros counter with veteran lefty Wandy Rodriguez, who's been tough to beat at Minute Maid Park.

Neftali Feliz pitched seven scoreless innings in his first Major League start and the Rangers held on for a 1-0 victory over the Mariners at Rangers Ballpark in Arlington on Tuesday night.