Jason Marquis carried a no-hitter into the sixth inning, Jedd Gyorko homered and Jesus Guzman went 3-for-4 with an RBI as the Padres defeated the Dodgers, 6-2, on Wednesday night in Los Angeles.

Wade Miley snapped a four-game losing streak with 6 2/3 strong frames, and Paul Goldschmidt launched his second grand slam of the week in the D-backs’ 10-3 win over the Cardinals on a rainy Wednesday night.

The Royals pounced with a three-run first inning and snapped their 11-game skid at Kauffman Stadium with a 4-1 victory over the Twins on Wednesday night.

The Astros erupted for six home runs — by six different players — for their biggest long-ball barrage in nearly seven years, and got another quality start from left-hander Dallas Keuchel and held on to beat the Orioles, 11-7, on Wednesday night at Minute Maid Park.

Anthony Rizzo smacked a three-run double with two outs in the 10th inning on Wednesday night to power the Cubs to an 8-6 victory over the Angels and split the brief Interleague series.

MLB received strong support Wednesday from an important and prominent ally, The World Anti-Doping Agency, in its investigation of Biogenesis.

After falling behind 4-1 in the first inning, the Rockies cruised to a blowout victory, 12-4, against the Reds in Cincinnati Wednesday night. Colorado hit six home runs, led by Carlos Gonzalez’s three and Troy Tulowitzki’s two.

Elvis Andrus hit a two-run double in the top of the seventh inning that lifted the Rangers to a 3-2 victory over the Red Sox on Wednesday night at Fenway Park.

Carlos Gonzalez hit three of the Rockies’ six home runs in Wednesday’s 12-4 rout of the Reds, his second career three-homer effort.

Based on the way Alex Cobb and Doug Fister were matching zeros, the chances of Wednesday’s game being decided by something small were great. Leave it to Sam Fuld to come up with the small. The diminutive outfielder employed a small-ball tactic that paid off big in launching a three-run ninth, and the Rays took a 3-0 win.

Marlon Byrd hit two home runs — as he predicted he would — David Wright added another and the Mets rapped out a season-high 15 hits in a 10-1 romp over the Nats.

Using Mariano Rivera as a starting pitcher in the All-Star Game is not as irresponsible as putting, say, Joey Votto at shortstop or Mike Trout at catcher, but it’s similar in this sense: They’d all be great players playing out of position.

It took 16 innings, more than 5 1/2 hours and overcoming blowing a five-run lead in the 14th, but the White Sox finally managed to end their eight-game losing streak with a 7-5 victory over the Mariners on Wednesday at Safeco Field.

Injured Dodgers starting pitcher Josh Beckett hopes four weeks of aggressive rehabilitation on his right shoulder will keep him out of the operating room.

From tablet apps to Twitter accounts, MLB.com is offering fans more ways than ever before to keep track of the First-Year Player Draft, coverage of which will get under way on MLB.com and MLB Network at 6 p.m. ET on Thursday.

The Rangers are sending first baseman Mitch Moreland back to Texas for an MRI exam on his right hamstring muscle. Moreland left the Rangers’ game with the Red Sox on Wednesday night in the seventh inning with tightness in the muscle.

Currently on a rehab assignment with Class A Advanced Jupiter, Giancarlo Stanton expects to return off the disabled list — barring any setbacks — on Monday when the Marlins open a six-game homestand against the Brewers.